Complex Family : 2ast
Query : Q6PEC4,RAT
  B2GUZ0,RAT
  B2RZ99,RAT
Selected Interface : 2astAB
No. of Contact Residue Pairs : 79
No. of Contact Residues in Chain 1 : 29
No. of Contact Residues in Chain 2 : 33
No. of Homologous Physical PPIs : 18
No. of Organisms : 9
MSA :  2astA side  (Query 1)
   2astB side (Query 2)
Template-Based Homologous Protein-Protein Interactions of 2astAB from Multiple Species
Organism Z-value Rank 2astA side (Query 1) 2astB side (Query 2)
uniprot AC Sequence Identity E-value
-log10()		 uniprot AC Sequence Identity E-value
-log10()
Homo sapiens 7.109 1 P63208 1.00 78.69 Q13309 1.00 100.00
Mus musculus 7.158 1 Q9WTX5 0.99 85.69 Q9Z0Z3 0.85 163.00
Rattus norvegicus 7.158 1 Q6PEC4 0.99 85.69 B2GUZ0 0.86 166.00
Bos taurus 7.178 1 Q3ZCF3 1.00 86.00 A7MB09 0.89 173.00
Danio rerio 6.328 1 Q6PBY8 0.98 85.30 A3KP53 0.50 90.52
Anopheles gambiae str. PEST 4.734 1 Q7Q8A7 0.83 68.39 Q7QI50 0.35 45.09
Nematostella vectensis 4.659 2 A7S0E4 0.91 66.22 A7RTZ4 0.33 34.52
Drosophila pseudoobscura pseudoobscura 6.196 1 Q28XZ2 0.72 56.52 Q295F1 0.35 52.00
Drosophila pseudoobscura pseudoobscura 5.874 2 Q29CI8 0.75 61.15 Q295F1 0.35 52.00
Drosophila pseudoobscura pseudoobscura 5.833 3 B5DS78 0.80 42.00 Q295F1 0.35 52.00
Drosophila pseudoobscura pseudoobscura 4.540 4 B5DMC8 0.41 20.30 Q295F1 0.35 52.00
Drosophila pseudoobscura pseudoobscura 4.237 5 B5DVK3 0.65 50.00 Q295F1 0.35 52.00
Drosophila pseudoobscura pseudoobscura 4.055 6 B5E1D5 0.50 36.00 Q295F1 0.35 52.00
Drosophila pseudoobscura pseudoobscura 3.976 7 B5DVK4 0.67 54.00 Q295F1 0.35 52.00
Aedes aegypti 5.207 1 Q0IEP2 0.83 69.69 Q17B55 0.34 46.04
Aedes aegypti 5.207 2 Q0IEP2 0.83 69.69 Q17B56 0.34 46.00
Aedes aegypti 5.201 3 Q16SA4 0.64 52.52 Q17B55 0.34 46.04
Aedes aegypti 5.201 4 Q16SA4 0.64 52.52 Q17B56 0.34 46.00

2astA side (Query 1)
                                     1010       1020      1030              1040      1050      1060                        1090       1100      1110      1120       1130      1140      1150      1160
2ast-A                       ASIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC

Query 1                      -TIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC

P63208   9606     PRI  3   : -SIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC

Q9WTX5   10090    ROD  3   : -TIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC
Q6PEC4   10116    ROD  3   : -TIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC

Q3ZCF3   9913     MAM  3   : -SIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC

Q6PBY8   7955     VRT  3   : -TIKLQSSDGEMFEVDVE-IAKQSVTIKTMLEDLGMDDEGDDDP--VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEK--RTDDIPV--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC

Q7Q8A7   180454   INV  3   : -TIKLQSSDGEIFDTDVQ-IAKCSGTIKTMLEDLGMD-EGDDEV--VPLPNVNSAILRKVLQWATFHKDDPIPVEDDDSKEK--RTDDISS--WDADFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTPAEEEQVRKENEWC
A7S0E4   45351    INV  3   : -NIKLQSSDGEIFEVDVE-IAKQSVTIKTMLEDLGMDED-DDDA--VPLPNVNAAILKKVIQWATRHKDDPPPPDDDENKEK--RTDDIEP--WDQEFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTPEEEEQVRKENEWC
Q28XZ2   46245    INV  4   : --IRLESSDKEIFDTDQE-IAKCSETIKTALEDLG--DESDNSV--LPLPNVNSLILKKVLHWATYHKDDAELAEEDENKEK--RTDDISS--WDADFLK-VDQGTLFELILAANYLNIQGLLDVTCKTVANMIKGGKSPQEIRDTFGITNDFSPSEEEQVRKENEWC
Q29CI8   46245    INV  3   : -NIKLQSSDEEIFDTDIQ-IAKCSGTIKTMLEDCGMEDD-ENAI--VPLPNVNSTILRKVLTWAHYHKDDPQPTEDDESKEK--RTDDIIS--WDADFLK-VDQGTLFELILAANYLDIKGLLELTCRTVANMIK-GKTPEEIRKTFNIKKDFTPAEEEQVRKENEWC
B5DS78   46245    INV  27  : -----------------------------------------------------------LLTWAHYHKDDPQPTEDDESKEK--RTDDIIS--WDADFLK-VDQGTLFELILAANYLDIKGLLELTCKTVANMIK-GKTPEEIRKTFNIKKDFTPAEEEQVRKENEWC
B5DMC8   46245    INV  5   : TTVKLQSSDGMIFEVDIDCITRCSGTIRRILESW-MDDE--DAV--VPLENIDSDILWMVREWAEFQFNCTG--------------DEARR--WVQNFVS-ADHAKLYGLIKAANYLDIKNLHNLTCKMVADMIR-GKKPEEMRRILLIPDDDSSFEESRDKPHFLW-
B5DVK3   46245    INV  3   : -NIKLQSAEMEIFETDIE-IAKCSGTIKAMLENC-VSENDEDSV--VPLKNVSSTILRKVLMWAEYHKDDPQSPDEDEKREKVKRTDDIIP--WDAEFLK-VDQGTLFGLMQAANYLDIKGLLEVSCNTVANMMM-CKTPEEIRKTFNIKKDFTPAEEEKERKENQWC
B5E1D5   46245    INV  4   : --VRLESSDGVVFDTDAD-TAKCSGTIKNMLEDCGLEHEEDHDHPIIPVPHVNSTILKMILTWAKYHMNDVPPAKDADKKDG--KMEEYPICEWDADFFSTVDHGTLFELIIAANYLDIRGLMNSACQTVANMIK-GHTPEQIRLIFNIPREPTEKD-----------
B5DVK4   46245    INV  3   : -NIKLQSAEMEIFETDIE-IAKCSGTIKAMLENCASEND-EDSV--VPLKNVSSTILRKVLMWAEYHKDDPQSPDEDEKREKVKRTDDIIP--WDAEFLK-VDQGTLFELMLAANYLDIKGLLVVSCKTVANMMR-GKTPEEMRKTFNIKKDFTPAEEEKVRKENQWC
Q0IEP2   7159     INV  3   : -NIKLQSSDGEVFDTDVQ-IAKCSGTIKTMLEDLGMD-EGEDEV--VPLPNVNSAILRKVLQWATYHKDDPAPAEDDENKEK--RTDDISS--WDADFLK-VDQGTLFELILAANYLDIKGLLDVTCKTVANMIK-GKTPEEIRKTFNIKNDFTPAEEEQVRKENEWC
Q16SA4   7159     INV  2   : SKIKLQSADGEVFEVEAS-IAKCSLTLRTMIDDLGIGQDCDD-V--VPLPNVHSCVLRKVLDWAIYHKHDHAIPADDP---E--RTDDICD--WDREFLC-VDQGMLFEIILAANYLDIRELLDLTCKTVANMIK-GKTPDQIRKTFNIRNDFTPEEEEQIRRENEWC
2astB side (Query 2)
                                    2100      2110      2120      2130      2140      2150      2160      2170                              2180              2190      2200      2210      2220      2230      2240      2250      2260      2270      2280      2290      2300      2310      2320      2330      2340      2350      2360      2370      2380      2390      2400      2410       
2ast-B                       PGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQP----LA-----EH----------FS-----P--------FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK

Query 2                      PGVSWDSLPDELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGVVAFRCPRSFMEQP----LG-----ES----------FS-----S--------FRVQHMDLSNSVINVSNLHGILSECSKLQNLSLEGLQLSDPIVTTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPDTLTQLNLSGYRKNLQKTDLCTLIKRCPNLVRLDLSDSIMLKNDCFPEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLREALPRLQINCAYFTSIARPTMDNKKNPEIWGIKCRLTLQK

Q13309   9606     PRI  93  : PGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQP----LA-----EH----------FS-----P--------FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK

Q9Z0Z3   10090    ROD  93  : PGVSWDSLPDELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGVVAFRCPRSFMEQP----LG-----ES----------FS-----S--------FRVQHMDLSNSVINVSNLHKILSECSKLQNLSLEGLQLSDPIVKTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPNTITQLNLSGYRKNLQKTDLCTIIKRCPNLIRLDLSDSIMLKNDCFPEFFQLNYLQHLSLSRCYDIIPDTLLELGEIPTLKTLQVFGIVPEGTLQLLREALPRLQINCAYFTTIARPTMDSKKNLEIWGIKCRLTLQK
B2GUZ0   10116    ROD  93  : PGVSWDSLPDELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGVVAFRCPRSFMEQP----LG-----ES----------FS-----S--------FRVQHMDLSNSVINVSNLHGILSECSKLQNLSLEGLQLSDPIVTTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPDTLTQLNLSGYRKNLQKTDLCTLIKRCPNLVRLDLSDSIMLKNDCFPEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLREALPRLQINCAYFTSIARPTMDNKKNPEIWGIKCRLTLQK

A7MB09   9913     MAM  93  : PGVSWDSLPDELLLGIFSCLCLPELLKVSSVCKRWYHLAFDESLWQTVDLAGRNLYPDVVGRLLSRGVVAFRCPRSFMDQP----LV-----EH----------FS-----P--------FRLQHLDLSNSVIDASTLHGLLSHCSKLQNLSLEGLRLSDPVVDNLAQNTNLLRLNLSGCSGFSESALKTLLSSCSRLDELNLSWCYDFTEKHVQMAVAHVSKTITQLNLSGYRKNLQRSDVSTLVGRCPNLVHLDLSDSVMLKNDCFPEFYQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLSLEK

A3KP53   7955     VRT  88  : ----WDSLPDELLLGIFSRLSLQDLLRTSRVCKRWHRLAFDESLWHSVDLVGKAQLDAELGQVLSAGVLRLRCPHTCIGQP----SF-----KS----------TP-----S--------LRVQHLDFSNCTVETSVLEDVLSRCKHLQNLSLEGLVLSDNIIYSLAQNPEIIRLNLCGCSGFSPESLTEMLTACTRIEEMNVSWC-DFSNLHIQAIASNIPSSVSQLNISGYRQNLTMEDVKAIVKRCPNITDLDLSDSVLVTTDSFPVLQQLSSLRHLGLSRCYQIHPASLIDFEKFLNLQTLEVFGLIQDSYLPILCKSLPHIQINTQPFSTVARPTSSSRKDRTLWGMHCRLVYK-

Q7QI50   180454   INV  73  : -------LSDEVLLHILKWLPKKTLLSCGQVNRRFNRVSKDETLWYRLDLSNRTLQFDGLVEVLSRGVIVLRLAQTSIVNP----TPDSNYLEF----------PA-----C--------IKVQYLDLSMCTVSLAVLGALLANCRALVKLSLENVPLDGRICAEIAENRKLEALNLTMCSGIDATGMRLMAKALTRLHSLNVSWT-SLSAEAVQELVRNLTPQIVHLNLSGCRSTLTDEKVAVLIKRCTKLVALDLSDCTPLTEVVIKTLCKARKIEYLSLSRCYNIPVTAYLNLTELKTLRFLDLFGLVSDQAIATLKNSLVDIGINKYYHSSVARPTVGTKRTS-IWGLRTR-----
A7RTZ4   45351    INV  6   : -------LADEVILGIFKLLPRDTLITCAQVCKHWLSLVYDESLWLTVDMSKAKLQHGLLGRILLRGTRVMRIASSRVCSP----LL-----DENLGILPGVAPLS-----PSMAACNSLFRLTYLDATLCTFEDSTLLTLLLHSRRLRCLSLDSSNLSLSILRAIGDCHDLEVLNLAMCTGITLQGVKALVNGCKRLTHLNLAWTHLSKESIIQVV--QNLPLLRQLNLSGSRETMTDEAVLHLISNCIHLTHLDLSDCILITARSLLAIIQETKIEHLALSRCYNIPPQAFSLCVELKSLAKLDVYGLLNGDGVEILKRQLPDTFINSCLFSTIARP-VDSKYRGTIWGIRCQ-----
Q295F1   46245    INV  235 : ----FDKLSDEILLDIFKWLPKKTLLRMATVSRRFNRCSRDETLWTRLDLGLRTLRPAALEQIVRRGVLVLRLAQANIQEPAFTPLA-----SD----------FK-----S---------RLQYLDLSMTSISRVSLRSLMSQCRQLKKLSLENAELSDEICAEIAKNKSLEALNLTMASGLTARSVRLMMESLTNLSSLNISWT-DLSADAVTALVTHISPNVIRLNVAGCRRVLFDSHVKSLQSRCPQLLELDLSDCNSLTPAAIEAIMQFQMLEYLSVSRCYLIPAASFIELKDMSSLTYLDIFGMLSDGAMEALEQQMPKMGINKFIHSSVSRPTVGSRRT-SIWGLRTR-----
Q17B55   7159     INV  74  : -------LSDEILLHIFRFLPKKALIRCSQVSKRFNQVSLDESLWARLDLSCRSLREGALGRVISRGTVILRLAQAHVSNP----VF-----TY----------GSVDLSYE--------TKLRFLDLSMCSIDQGTLCELLSHCRSLRKLSLENVPVDTECCREIACNVHLEALNLTMCEGLDNFNVTLLIKKLTKLHSLNISWT-QLSRSTVDSLVTHVTPTLLRLNIAGCRNSMTDAALLKLIDRCPDLLELDLSDCTQLSSEAMKIVCKLKKLEYLSLSRCYNINVTSYLQLGAIEPLQFLDIFGLLSEPALAMLQTSFPGVGINKFMHSSVARPTVGSRRT-SIWGLRTR-----
Q17B56   7159     INV  151 : -------LSDEILLHIFRFLPKKALIRCSQVSKRFNQVSLDESLWARLDLSCRSLREGALGRVISRGTVILRLAQAHVSNP----VF-----TY----------GSVDLSYE--------TKLRFLDLSMCSIDQGTLCELLSHCRSLRKLSLENVPVDTECCREIACNVHLEALNLTMCEGLDNFNVTLLIKKLTKLHSLNISWT-QLSRSTVDSLVTHVTPTLLRLNIAGCRNSMTDAALLKLIDRCPDLLELDLSDCTQLSSEAMKIVCKLKKLEYLSLSRCYNINVTSYLQLGAIEPLQFLDIFGLLSEPALAMLQTSFPGVGINKFMHSSVARPTVGSRRT-SIWGLRTR-----
Description
Template
(structure)		 Contact residues: Marked by 4 colors
Hydrogen-bond residues: green Conserved residues:orange Both:yellow Others:gray